1. Acquisition of common stock resulting from vesting of the restricted stock units granted to Mr. von Autenried on October 7, 2022.

2. Each restricted stock unit represents a contingent right to receive one share of Science 37 Holdings, Inc.'s common stock.

3. On October 7, 2022, Mr. von Autenried received restricted stock units representing 46,040 shares, vesting in full on the earlier of the one-year anniversary of the grant date and the date of the Company's next annual stockholder meeting following the grant date. As restricted stock units vest, the vested units are automatically converted to vested common stock on a one-for-one basis on the vesting date.

4. On May 11, 2023, Mr. von Autenried received restricted stock units representing 494,853 shares, vesting in full on the earlier of the one-year anniversary of the grant date and the date of the Company's next annual stockholder meeting following the grant date. As restricted stock units vest, the vested units are automatically converted to vested common stock on a one-for-one basis on the vesting date.