1. Acquisition of common stock resulting from vesting of the restricted stock units granted to Ms. Pellizzari on May 20, 2022.

2. Disposition of common stock resulting from the withholding of securities for the payment of tax liability relating to the vesting of one-third of the restricted stock units granted to Ms. Pellizzari on May 20, 2022.

3. Each restricted stock unit represents a contingent right to receive one share of Science 37 Holdings, Inc.'s common stock.

4. On May 20, 2022, Ms. Pellizzari received restricted stock units representing 50,000 shares subject to a three-year vesting schedule, vesting 33 1/3% on the first, second and third anniversaries of the grant date. As restricted stock units vest, the vested units are automatically converted to vested common stock on a one-for-one basis on the vesting date.