ORBIMED ADVISORS LLC's most recent trades

Director, 10% Owner

COMPANY

NET TOTAL

20.36%

Other

292,842,000

$1,054,202,000.00

6.75%

SINOVAC BIOTECH LTD

2,718,735

$349,500,000.00

3.75%

BRISTOL-MYERS SQUIBB CO

2,518,700

$193,940,000.00

3.31%

HUMANA INC

365,700

$171,173,000.00

3.25%

HORIZON THERAPEUTICS PUB L

2,108,555

$168,178,000.00

3.15%

BOSTON SCIENTIFIC CORP

4,369,500

$162,851,000.00

2.93%

TURNING POINT THERAPEUTICS I

2,012,250

$151,422,000.00

2.87%

SPRINGWORKS THERAPEUTICS INC

6,028,307

$148,417,000.00

2.79%

UNITEDHEALTH GROUP INC

281,200

$144,433,000.00

2.78%

PFIZER INC

2,744,000

$143,868,000.00

2.72%

BIOMARIN PHARMACEUTICAL INC

1,699,710

$140,855,000.00

2.52%

SEAGEN INC

737,500

$130,493,000.00

2.37%

ABBVIE INC

799,800

$122,497,000.00

2.17%

EDGEWISE THERAPEUTICS INC

14,082,680

$112,098,000.00

2.11%

VERTEX PHARMACEUTICALS INC

387,200

$109,109,000.00

2.10%

ADICET BIO INC

7,447,141

$108,728,000.00

2.09%

SIERRA ONCOLOGY INC

1,964,770

$108,043,000.00

2.02%

BIOHAVEN PHARMACTL HLDG CO L

719,034

$104,770,000.00

2.01%

INTUITIVE SURGICAL INC

517,200

$103,807,000.00

1.97%

ARCUTIS BIOTHERAPEUTICS INC

4,781,646

$101,897,000.00

1.92%

TRICIDA INC

10,280,947

$99,520,000.00

1.86%

EDWARDS LIFESCIENCES CORP

1,011,300

$96,165,000.00

1.81%

PMV PHARMACEUTICALS INC

6,563,077

$93,524,000.00

1.70%

STRYKER CORPORATION

441,100

$87,748,000.00

1.60%

NEUROCRINE BIOSCIENCES INC

849,545

$82,814,000.00

1.42%

ARGENX SE

194,000

$73,503,000.00

1.41%

MIRATI THERAPEUTICS INC

1,090,400

$73,199,000.00

1.26%

GLOBAL BLOOD THERAPEUTICS IN

2,044,000

$65,306,000.00

1.24%

NATERA INC

1,811,353

$64,194,000.00

1.19%

THERMO FISHER SCIENTIFIC INC

113,400

$61,608,000.00

1.15%

CRINETICS PHARMACEUTICALS IN

3,196,876

$59,622,000.00

1.12%

COMPASS THERAPEUTICS INC

21,960,850

$58,196,000.00

1.05%

EVOLENT HEALTH INC

1,778,000

$54,602,000.00

1.01%

PRELUDE THERAPEUTICS INC

10,039,691

$52,407,000.00

0.99%

KINNATE BIOPHARMA INC

4,043,629

$50,990,000.00

0.91%

ABCELLERA BIOLOGICS INC

4,430,768

$47,188,000.00

0.90%

REPARE THERAPEUTICS INC

3,322,488

$46,482,000.00

0.90%

KEROS THERAPEUTICS INC

1,679,417

$46,402,000.00

0.86%

SYNDAX PHARMACEUTICALS INC

2,323,300

$44,700,000.00

0.86%

SI-BONE INC

3,368,000

$44,458,000.00

0.84%

GUARDANT HEALTH INC

1,083,400

$43,704,000.00