RTW INVESTMENTS, LP's most recent trades

Director, 10% Owner, See Remarks

COMPANY

NET TOTAL

6.79%

ALNYLAM PHARMACEUTICALS INC

1,683,362

$245,518,000.00

6.56%

Other

48,417,864

$236,917,000.00

6.55%

THERMO FISHER SCIENTIFIC INC

435,500

$236,598,000.00

6.02%

ROCKET PHARMACEUTICALS INC

15,802,802

$217,447,000.00

5.59%

PTC THERAPEUTICS INC

5,045,307

$202,115,000.00

4.88%

MASIMO CORP

1,350,993

$176,534,000.00

4.64%

ARGENX SE

442,635

$167,706,000.00

4.13%

IMMUNOCORE HLDGS PLC

3,996,154

$149,097,000.00

3.56%

ESTABLISHMENT LABS HLDGS INC

2,369,138

$128,834,000.00

3.50%

MIRATI THERAPEUTICS INC

1,882,663

$126,383,000.00

2.88%

ILLUMINA INC

564,375

$104,048,000.00

2.78%

CYTOKINETICS INC

2,561,182

$100,629,000.00

2.49%

PROMETHEUS BIOSCIENCES INC

3,189,605

$90,043,000.00

2.45%

VERICEL CORP

3,522,904

$88,707,000.00

2.41%

PENUMBRA INC

698,371

$86,961,000.00

2.30%

CELLDEX THERAPEUTICS INC NEW

3,084,215

$83,150,000.00

2.27%

ULTRAGENYX PHARMACEUTICAL IN

1,373,284

$81,930,000.00

2.08%

NATERA INC

2,122,283

$75,214,000.00

1.93%

AVIDITY BIOSCIENCES INC

4,795,000

$69,671,000.00

1.85%

AXONICS INC

1,179,965

$66,869,000.00

1.84%

CUTERA INC

1,770,400

$66,390,000.00

1.74%

GLOBUS MED INC

1,121,527

$62,963,000.00

1.73%

PMV PHARMACEUTICALS INC

4,395,677

$62,638,000.00

1.72%

AXSOME THERAPEUTICS INC

1,618,819

$62,001,000.00

1.65%

ACADIA PHARMACEUTICALS INC

4,224,109

$59,518,000.00

1.60%

ADICET BIO INC

3,951,281

$57,689,000.00

1.51%

TANDEM DIABETES CARE INC

922,630

$54,610,000.00

1.39%

RELMADA THERAPEUTICS INC

2,637,581

$50,088,000.00

1.33%

STOKE THERAPEUTICS INC

3,651,823

$48,241,000.00

1.26%

REGENXBIO INC

1,845,366

$45,581,000.00

1.20%

10X GENOMICS INC

959,481

$43,417,000.00

1.05%

PROTAGONIST THERAPEUTICS INC

4,794,499

$37,924,000.00

1.03%

GUARDANT HEALTH INC

924,887

$37,310,000.00

0.81%

QUANTERIX CORP

1,819,120

$29,452,000.00

0.81%

TARSUS PHARMACEUTICALS INC

2,013,601

$29,399,000.00

0.73%

MILESTONE PHARMACEUTICALS IN

4,315,102

$26,538,000.00

0.69%

VERU INC

2,220,983

$25,097,000.00

0.59%

BICYCLE THERAPEUTICS PLC

1,276,276

$21,416,000.00

0.56%

CASTLE BIOSCIENCES INC

913,789

$20,058,000.00

0.55%

APYX MEDICAL CORPORATION

3,398,279

$19,914,000.00

0.54%

FULCRUM THERAPEUTICS INC

3,961,194

$19,410,000.00